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LAVIV™ ( azficel-T) is the first and only personalized cell therapy approved by the FDA for aesthetic use to improve the appearance of moderate to severe nasolabial fold wrinkles (smile lines) in adults. The patented technology uses an advanced process to extract fibroblast cells from a person via a small skin sample. Then these cells are multiplied in a Fibrocell Science lab. Fibroblast cells are responsible for producing collagen, which gives skin its tone, structure and overall quality. This process takes about 90 days for the cells to be cultured and ready for injection back into the patient, usually given in a series of three treatments about 3 to 6 weeks apart. LAVIV™ is clinically proven to be a safe and effective treatment for smile lines on the face.